How to Create Successful Cannabis Ecommerce Websites In the case of cannabis e-commerce, the potential is immense. With the amount of people using the drug rises, the ecommerce market will also expand, making it easy for brands to advertise their products. The main issue with traditional retail can be the legal structure, and ecommerce is the best solution. But, as with every emerging industry there are a few challenges to overcome before an online store can be a major success.