Collagen inside the intervertebral disc, but is essential for the sustaining the interactions between PG and collagens [868]. It can be a heterotrimeric triple-helix molecule produced of 3 chains 1(XI), two(XI), and three(XI) [89]. There are many various COL11 single nucleotide polymorphisms (SNPs) that have been associated with degeneration, even so none have so far been replicated in other popu